Synthesis, Spectra and Antibacterial Studies of 4-{[(E)-phenylmethyl- idene]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide Schiff Base Ligand and its Ni(II) Complex


  • Ifeanyi E. Otuokere Michael Okpara University of Agriculture, Umudike, Nigeria
  • J.C. Anyanwu Michael Okpara University of Agriculture, Umudike, Nigeria
  • K.K. Igwe Michael Okpara University of Agriculture, Umudike, Nigeria


Schiff base, synthesis, benzaldehyde,, sulphathiazole, Ni2 , characterization, antibacterial assay


Communication in Physical Sciences 2021, 7(2):115-125

Authors: Ifeanyi. E. Otuokere, J.C Anyanwu and K.K Igwe

Received 09 April 2021/Accepted 01 June 2021

A novel Schiff base and its Ni(II) complex have synthesized from benzaldehyde and sulphathiazole. The synthesized products were characterized using elemental analyser, ultra violet visible, Fourier transformed infra red, proton and carbon-13 spectrophotometers. Results obtained from infra red spectrum suggested that the ligand is coordinated to nickel ions through two azomethine nitrogen, and one amine nitrogen. Electronic spectral measurement indicated that there is a ligand to metal charge transfer and from the continuous variation method, metal: ligand ratio of 1:1 was proposed. Elemental analysis and spectroscopic studies suggested that the Schiff base behaved as a tridentate ligand towards nickel ion. In vitro antibacterial sensitivity tests of the ligand and its Ni  (II)  complex against Staphylococcus aureus, Echerichia coli, Pseudomonas aeruginosa and Salmonella typhi showed that they exhibited strong activities. However, the Ni(II) complex was observed to be more potent than the  Schiff base.


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Author Biographies

Ifeanyi E. Otuokere, Michael Okpara University of Agriculture, Umudike, Nigeria

Department of Chemistry

J.C. Anyanwu, Michael Okpara University of Agriculture, Umudike, Nigeria

Department of Chemistry

K.K. Igwe, Michael Okpara University of Agriculture, Umudike, Nigeria

Department  of Veterinary Biochemistry and Animal Production


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